Endocrine Abstracts

Background: To evaluate the technical feasibility, effectiveness, and safety of transoral robotic thyroidectomy (TORT), using the da Vinci system through analysis of our series of 1000 consecutive patients.Method: A review of a prospectively designed database at our institute from September 2012 to February 2022 revealed a series of 1000 consecutive TORT patients with preoperative diagnosis of various thyroid diseases. Clinicopathologic characteristics a...

Objective: Diabetes mellitus (DM) is known to be associated with a lower trabecular bone score (TBS) and an increased risk of fracture. However, little is known regarding whether it is associated with poor bone results in pre-diabetic individuals. Despite the fact that both IFG and IGT are characterized by insulin resistance and β-cell dysfunction, the metabolic abnormalities are quite distinct between the two disorders. Impaired fasting glucose (IFG) was marked by dysfun...

Background: Guanine nucleotide-binding protein, α stimulating (GNAS) gene have been reported to be associated with GH secreting pituitary adenoma. Approximately 40% of patients with acromegaly have GNAS mutation. In this study, we investigated the prevalence of GNAS mutation in Korean acromegalic patients and assessed the correlation with the biochemical or clinical characteristics.Method: We studied acromegalic patients who underwent surgery betwee...

Objective: Although rapid adrenocorticotrophic hormone (ACTH) stimulation test is a standard test for primary and secondary adrenal insufficiency (AI), it is considered a costly and time-consuming method due to sampling three times in an hour. We aimed to develop a simpler diagnostic model of secondary AI using non-fasting basal cortisol and clinical parameters related to AI such as history of exogenous steroid use or hyponatremia.Methods: Total 430 pati...

Background: The 2015 ATA guidelines recommend total thyroidectomy with therapeutic central lymph node dissection (CND) for papillary thyroid carcinoma (PTC) patients with clinical central lymph node metastasis (CLNM). The purpose of this study is to verify that total thyroidectomy with therapeutic bilateral CND is necessary for all patients with unilateral cN1a PTC.Methods: This study retrospectively reviewed 899 PTC patients who had total thyroidectomy ...

Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into various types of cells including chondrocytes, osteoblasts and adipocytes. Since these types of cells are simultaneously derived from the same precursor cell, adipogenesis and osteoblastogenesis are thought to be counter-related. It is well-known that chronic treatment of steroid can induce Cushing’s syndrome which has phenotypes like visceral adiposity and osteoporosis. Cell fate of d...

Background: Optimal production of cellular energy and metabolites in mitochondria is one of the most important factors in endocrine organs that accomplish the momentary adaptation to ligand stimulation, such as insulin secretion and aldosterone biosynthesis. Although it has been suggested that thyroid gland function is also largely dependent on mitochondrial function, functional behavior of thyroid gland on compromised mitochondrial function remained to be identified. In this ...

Introduction: Transoral Robotic Thyroidectomy (TORT) is progressively gaining its ground in robotic thyroid surgery. With accumulated techniques and developments, TORT can also be applied for completion thyroidectomy. We review our experience with the transoral robotic approach to completion thyroidectomy to evaluate the safety and surgical feasibility.Methods: Consecutive patients receiving completion TORT operation were evaluated from a prospective dat...

Background: Given the possible association between dipeptidyl peptidase-4 (DPP-4) inhibitor and risk of diabetic retinopathy (DR), we examined whether DPP-4 inhibitors are beneficial or harmful for DR compared with other glucose-lowering agents.Methods: From a Korean population-based cohort, we identified 67,743 adults with type 2 diabetes treated with oral glucose-lowering agents between 2008 and 2013. Matching (1:1) was done for comparative groups: eve...

Background: Although sclerostin (SOST) and Dickkopf-related protein 1 (DKK1) are major regulators in bone metabolism, the associations between these soluble Wnt antagonists and osteoporotic fracture (OF) in Asians, who may have distinct biologic characteristics with Caucasians, are inconclusive. Furthermore, there have been no clinical studies separately considering non-vertebral and vertebral fractures in terms of the blood levels of SOST and DKK1.Metho...